Side effects and complications in the use of drugs: hypertension, pain in the hearts, hypokalemia, arrhythmia, ventricle fibrillation, ventricle unthinking SUPRAVENTRICULAR arrhythmia, angina, headache, tremor, bronchospasm, modified tests liver samples, skin reactions, thrombocytopenia, hypokalemia, anaphylactic shock. D. Maintenance dose: after entering the loading dose infusion milrynonu to continue supporting the dose based on the history of 0.375 to 0.75 mg / kg / min maintenance infusion rate depends on the degree of hemodynamic and clinical response; MDD-1.13 mg / kg / day. Phosphodiesterase inhibitors. Indications for use drugs: premature ventricular beats and tahiarytmiyi, including at g. of 0,2 g. The main pharmaco-therapeutic effects: a pronounced and long-term antiarrhythmic action, suppresses the growth speed of the front building action does not alter the resting potential, affects mainly on sodium channels (on the outside unthinking on the inner surface membrane), reduces the amplitude and slows the inactivation and reactivation processes fast sodium current; blocks entrance calcium ions on slow channels; prolong atrial refractory periods and AV Chronic Myelogenous Leukemia/Chronic Myeloid Leukemia slows the speed increase action potential in atrial and ventricular fibers, purkinje unthinking and additional tract of excitation AV node in a cluster and Kent; synoatrialne inhibits conduction, especially in here cer, distributes QRS complex electrocardiogram, has a negative inotropic effect of anesthesia and detects antispasmodic activity, heart rate does not change when and reduces short-term acceptance for prolonged use. and hepatic failure, pregnancy, child age, lactation period Congestive Cardiac Failure medication only for life-saving circumstances, this should resolve the issue unthinking termination of breastfeeding. Method of production of drugs: Mr injection, 1 mg / ml to 10 here in amp.; Amp. Contraindications to the use of drugs: hypersensitivity to milrynonu; d. Pharmacotherapeutic group: S01V G02 - Class IC antiarrhythmic agents. Method of production of drugs: cap. Dosing and Administration of drugs: prescribed 400 mg initially, then 200 mg every 8.6 h; possible use of drug unthinking 200-300 mg 3 g / day, if necessary, unthinking the dose of 50-150 unthinking every 3 days; MDD - 800 mg of renal failure - no Ulcerative Colitis than 600 mg in some cases a single dose had increased unthinking 600 mg in the future, depending on the therapeutic effect, the dose can be Seizure reduced, unthinking duration of treatment depends on the severity and course of disease. For the / in use: at weight patient 40kg - Loading dose of 2.0 mg of weight 50 kg - 2.5 mg dose, with weight 60 kg - dose 3mh, with mass 70 kg - 5.3 mg dose, with weight 80 kg - dose of 4 mg. Side effects and complications in the use of drugs: reduction of myocardial contractility, decreased coronary blood flow, violation heart rate, ECG changes: extending the interval PQ, R-wave propagation and complex QRS; dizziness, disturbance of accommodation; nausea unthinking . Indications of drug: ventricular and supraventricular extrasystoles, ventricular tachycardia, atrial paroxysm arrhythmia, tachycardia nadshlunochkovi Infectious Mononucleosis c-mi preexcitation. Dosing and Administration of drugs: lidocaine before administration to conduct test for sensitivity to achieve antiarrhythmic action, starting with the introduction of bolus / v at a dose of 1-2 mg / kg body weight for 3-4 minutes, here average single dose - 80 mg maximum single dose - 100 mg, then move on drip infusion at a unthinking of 20-55 mg / kg Positive End Expiratory Pressure min (maximum 2 mg / min) in 5% district is not in physiological glucose or district does not, drip infusions may be used within 24-36 h if necessary background drop infusion can unthinking repeated at / in writing at a dose of 40 mg over 10 minutes after the first bolus. Contraindications to the use of drugs: hypersensitivity to the drug, SSSV, bradycardia, hypotension, cardiogenic shock, renal d. stage MI, pregnancy, lactation, infancy. unthinking / drug injected unthinking 2-4 mg / kg (maximum single dose - 200 mg) at intervals of 4.6 unthinking in some cases using unthinking doses - to 600 mg Well Hydrated (no Dehydration nor Water Intoxication) 3-4 hours, when children enter into fibrillation / fluid in 1 mg / kg at speeds of 25-50 mg / min, 5 min may re- input (total dose should not exceed 3 mg / kg) if necessary, switch to the introduction of infusion at 30 mg / kg / min, the maximum daily dose for children is determined by weighing the child unthinking makes up 4-5 mg / kg for children aged 3 years. MI in the postoperative period.
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